BPC-157
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- 99.2% Purity
- 5mg vial
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Certificate of Analysis
Scientific Overview
BPC-157, also known as Body Protection Compound-157, is a synthetic pentadecapeptide composed of 15 amino acids. It is derived from a partial sequence of body protection compound (BPC) isolated from human gastric juice. BPC-157 has demonstrated stability in human gastric juice, distinguishing it from many other peptides that degrade rapidly in acidic environments. It has been the subject of extensive preclinical research examining its interactions with various biological pathways.
Chemical Makeup
Molecular Formula
C₆₂H₉₈N₁₆O₂₂
Molecular Weight
1419.53 g/mol
Amino Acid Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
CAS Number
137525-51-0
Other Names
Pentadecapeptide BPC 157, PL 14736, PL-10, Body Protection Compound-157
Appearance
White to off-white lyophilized powder
Storage
Store refrigerated at 2–8°C. For extended storage, keep frozen at -20°C. Protect from light and moisture.
Research & Clinical Studies
BPC-157 and Wound Models
In a preclinical study using three experimental murine models — skin tissue wounds, colon tissue anastomosis, and synthetic sponge implantation — BPC-157-treated subjects exhibited higher counts of collagen fibers, reticulin fibers, and blood vessel formation compared to control groups. Histological examination noted differences in granulation tissue formation and re-epithelialization rates between treated and control cohorts.
BPC-157 and Tendon Fibroblast Studies
Cultured tendon fibroblasts derived from murine models were exposed to BPC-157 in vitro. Results indicated greater tendon fibroblast outgrowth, higher cell survival rates under oxidative (H₂O₂) stress, and greater cell migration compared to controls. Analysis suggested involvement of the FAK-paxillin signaling pathway and F-actin formation.
BPC-157 and Gastrointestinal Studies
Comparative studies evaluated BPC-157 alongside angiogenic growth factors (EGF, FGF, VEGF). BPC-157 produced consistent results across multiple wound types — chronic and acute — on the esophagus, stomach, duodenum, and lower GI tract in preclinical models. Its stability in gastric juice was noted as a distinguishing characteristic.
BPC-157 and Central Nervous System Models
In a murine traumatic brain injury (TBI) model, BPC-157 groups showed differences in severity of subarachnoid hemorrhage, intraventricular hemorrhage, and brain laceration compared to controls. Observations noted differences in brain edema measurements in the treated cohort during the 24-hour post-injury period.
References
- 1. Chang, C.H. et al. "The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration." J Appl Physiol. 110(3):774-80 (2011). View
- 2. Seiwerth, S. et al. "BPC 157's effect on healing." J Physiol Paris. 91(3-5):173-8 (1997). View
- 3. Huang, T. et al. "Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro." Drug Des Devel Ther. 9:2485-2499 (2015). View
- 4. Tudor, M. et al. "Traumatic brain injury in mice and pentadecapeptide BPC 157 effect." Regul Pept. 160(1-3):26-32 (2010). View
