AOD-9604

AOD-9604

Modified hGH fragment peptide for metabolic pathway research.
  • 99% Purity
  • 2MG

$29.00

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Certificate of Analysis

Third Party Tested by Third-Party HPLC Lab
Variant

AOD-9604 2mg

Lot #

TPM-0302

Labeled

2mg

Actual

2.04mg

Tested Feb 1, 2026

View COA Library

Scientific Overview

AOD-9604 is a modified fragment of the C-terminal region of human growth hormone (hGH), specifically amino acids 176-191, with the addition of a tyrosine residue at the N-terminus. It was developed to isolate the lipolytic activity of growth hormone from its growth-promoting effects. AOD-9604 received GRAS (Generally Recognized As Safe) designation from the US FDA in 2014.

Chemical Makeup

Molecular Formula

C₇₈H₁₂₃N₂₃O₂₃

Molecular Weight

1815.01 g/mol

CAS Number

221231-10-3

Other Names

Anti-Obesity Drug 9604, Tyr-hGH Fragment 177-191

Appearance

White to off-white lyophilized powder

Storage

Store refrigerated at 2–8°C. For extended storage, keep frozen at -20°C. Protect from light and moisture.

Research & Clinical Studies

Lipolytic Activity without Growth Effects

Preclinical studies observed that AOD-9604 interacts with lipolysis and lipogenesis pathways in adipose tissue without the diabetogenic, growth-promoting, or IGF-1-stimulating characteristics of full-length hGH. These observations were documented in both in vitro adipocyte assays and in vivo obese mouse models.

Phase 2 Clinical Evaluation

A randomized, double-blind, placebo-controlled phase 2b trial evaluated oral AOD-9604 in obese subjects over 24 weeks. The study assessed body weight change, waist circumference, and metabolic parameters. Results contributed to the compound's safety profile characterization.

References

  • 1. Ng, F.M. et al. "Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone." Horm Res. 53(6):274-8 (2000). View
  • 2. Heffernan, M. et al. "The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice." Endocrinology. 142(12):5182-9 (2001). View

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Frequently Asked Questions

What is the purity of AOD-9604?
Our AOD-9604 is verified at 98.5% purity through independent third-party HPLC analysis. Each production batch undergoes rigorous quality testing, and a Certificate of Analysis (COA) is available for review in our COA Library.
Store refrigerated at 2–8°C. For extended storage, keep frozen at -20°C. Protect from light and moisture. Once reconstituted, solutions should be used promptly or stored frozen to maintain stability. Avoid repeated freeze-thaw cycles for best results.
Yes — every batch we produce is independently tested via HPLC and mass spectrometry to confirm identity and purity. COAs for all current batches are publicly accessible through our COA Library.
All orders ship within 24 hours of purchase via USPS Priority Mail. Products are carefully sealed and packaged to ensure stability during transit. Orders over $150 qualify for free shipping. If you receive a damaged, defective, or incorrect product, please contact our support team with photos within 48 hours of delivery.
No. This product is sold exclusively for in-vitro laboratory and research purposes. It is not intended for human or animal consumption, nor for any diagnostic or therapeutic applications. Purchasers must be 18 years of age or older and assume full responsibility for lawful handling.
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